The PL2303RA chipset from Prolific can be found in a number of devices. The most common location for this chipset can be found in the USB to RS232 Bridge Controller which you will find in the StarTech 2 Port USB to RS232 Serial DB9 Adapter Cable. You can find the driver for this cable listed below as the Prolific USB to serial driver on this.
Pl 2303 Vista Driver
I'm afraid that there is no solution..
There is lot's of people reporting problems with W10 and Prolific devices (based on popular PL2303 adapter).
Myself, I've the same problems with scrolling LED Badges, and USB to COM dongles. All this devices use a PL2303 to provide a connection to an USB port, but inside, they are RS232-like interface build (and appear as a COM port in your operating system). When you plug the device into USB, it is well recognized by W10 and it try to load the Prolific driver. This work fine, but looking at the configuration panel, you will then notice that there is an error code 10 and the driver is not working properly.
There is lot's of people reporting problems with W10 and Prolific devices (based on popular PL2303 adapter).
Myself, I've the same problems with scrolling LED Badges, and USB to COM dongles. All this devices use a PL2303 to provide a connection to an USB port, but inside, they are RS232-like interface build (and appear as a COM port in your operating system). When you plug the device into USB, it is well recognized by W10 and it try to load the Prolific driver. This work fine, but looking at the configuration panel, you will then notice that there is an error code 10 and the driver is not working properly.
Prolific 2303 Driver Windows 7
Prolific PL-2303 - Cable (CA-42 Generic) Free Driver Download for Windows 2008, Vista, 2003, XP, 2000, ME, 98SE. World's most popular driver download site. Direct link PL2303ProlificDriverInstallerv1.12.0.exe Download, download PL2303ProlificDriverInstallerv1.12.0.exe 4shared for all, at: 2015-11-22T23:51:41.000Z. Minimal ADB and Fastboot Tool helps in installing ADB and Fastboot drivers on your windows machine. So, that you can use ADB or Fastboot commands to perform some tasks like adb. Note that we have updated the Prolific driver for the Prolific USB to serial driver which you now download below for Windows XP/7/8/10 listed below. Install the Prolific USB to Serial driver on Windows. Double-click the PL-2303 Windows Driver Installer program.
Of course, you can try to manually update the driver at Prolific site:
Prolific Pl 2303 Ra Driver Login
But, look carefully on this page and you will read an important notice in RED :
Windows 8/8.1/10 are NOT supported in PL-2303HXA and PL-2303XEOL (End Of Life) chip versions.
This is clear: if your device is using an old chip version of PL2303, the drivers not works with W10 (and W8).
As many people, you probably upgrade directly from W7 to W10, and sure, don't know that this problem was already present with W8. It's a shame from Prolific to not support this devices, because they are still used (my LED badges are less than a year old, and use EOL PL-2303 HX). Prolific's guys are fun when they said : 'Prolific recommends to use PL-2303HXD (HX Rev D) or PL2303TA chip.' . Hey, but I can't do that myself !!!
Ser2pl.sys
I don't want to send my devices to trash because they are too old (less than a year !) to be supported by W10.
May be, a solution will be to use the old W7 drivers version into W10. Not tested.. I will try..
For the most part, I have been pleased with the StarTech products I have purchase. However, I continue to fight this device and it's functionality in Windows 10. With the Prolific drivers I have been able to get this working and identify the chipset as PL-2303 RA which is listed as supported on WIndows 10. Currently it is hit or miss, as to if the connected USB is correctly identified and linked to the device/driver instance. At this point, I can't tell if it's poor drivers or a counterfeit chip. Very disappointing and a frustrating waist of time and money!May be, a solution will be to use the old W7 drivers version into W10. Not tested.. I will try..
I have a similar product (Null Modem USB to Serial) from StartTech with a FTDI chipset. It has worked flawlessly. I will be investigating a standard USB to Serial adapter utilizing the FTDI chipset in hopes of having a stable product when needed.